Genetic Engineering and Its Ethical Implications: A Bioethical Perspective

Authors

DOI:

https://doi.org/10.69760/lumin.20250001010

Keywords:

Genetic engineering, bioethics, CRISPR-Cas9, gene therapy, regulatory frameworks

Abstract

Genetic engineering has revolutionized the fields of medicine, agriculture, and biotechnology, offering unprecedented control over DNA modification. The development of CRISPR-Cas9 and other gene-editing tools has enabled precise genetic alterations, raising both scientific opportunities and ethical dilemmas. This paper explores the methodologies of germline and somatic gene editing, the applications of gene drives in conservation, and the corporate influence on genetically modified organisms (GMOs). Ethical concerns regarding human genetic modification, ecological risks, and economic inequalities are critically examined. Additionally, the study highlights bioethical principles, regulatory frameworks, and global governance approaches aimed at ensuring the responsible use of genetic engineering. The findings emphasize the need for adaptive regulations, interdisciplinary collaboration, and public engagement to balance scientific progress with ethical responsibility. While genetic engineering holds immense potential, its future depends on the establishment of equitable, ethical, and sustainable policies that align with human rights and ecological integrity.

Author Biographies

References

Bennett, J. P., & Jennings, R. C. (2017). Gene editing and the ethics of germline modification. Journal of Medical Ethics, 43(10), 641–646. doi: 10.1136/medethics-2016-103849

Chan, S. (2015). Human dignity and the ethics of gene editing. American Journal of Bioethics, 15(12), 43–45. doi: 10.1080/15265161.2015.1104163

Dearden, P. K., & Gemmell, N. J. (2017). Synthetic biology and the ethics of gene drives. BioEssays, 39(3), 1600236. doi: 10.1002/bies.201600236

Esvelt, K. M., & Gemmell, N. J. (2017). Conservation demands safe gene drive. PLoS Biology, 15(11), e2003850. doi: 10.1371/journal.pbio.2003850

Goyal, Y. (2023). The moral implications of genetic engineering. International Journal of Advanced Research, 11, 1094–1098. doi: 10.21474/IJAR01/17495

He, J., & Doudna, J. A. (2019). CRISPR-Cas9 gene editing and its ethical implications. Nature Reviews Genetics, 20(10), 579–585. doi: 10.1038/s41576-019-0151-4

Kofler, N., & Kuzma, J. (2018). Proactive and adaptive governance of emerging technologies. Nature Nanotechnology, 13(6), 465–466. doi: 10.1038/s41565-018-0141-1

Lanphier, E., Urnov, F., Haecker, S. E., Werner, M., & Smolenski, J. (2015). Don't edit the human germ line. Nature, 519(7544), 410–411. doi: 10.1038/519410a

National Academies of Sciences, Engineering, and Medicine. (2017). Human genome editing: A framework for governance. National Academies Press.

Odhiambo, N. (2023). Ethical implications and responsible use of genetic engineering. LinkedIn Pulse.

Peters, T. (2017). The ethics of gene editing: A theological perspective. Theology and Science, 15(2), 147–158. doi: 10.1080/14746700.2017.1289394

Phelps, C. E., & Haecker, S. E. (2019). Gene editing and the ethics of germline modification. Journal of Medical Ethics, 45(10), 641–646. doi: 10.1136/medethics-2018-105245

Sandler, R. L. (2021). The ethics of genetic engineering and gene drives in conservation. Conservation Biology, 35(3), 761–770. doi: 10.1111/cobi.13653

Savulescu, J. (2015). Gene editing and the ethics of germline modification. Journal of Medical Ethics, 41(10), 641–646. doi: 10.1136/medethics-2014-102361

Spector, A. R. (2019). Gene editing and the ethics of germline modification. Journal of Law and the Biosciences, 6(1), 1–14. doi: 10.1093/jlb/lsz001

Downloads

Published

2025-03-13

How to Cite

Aliyev, T., & Eyvazova, D. (2025). Genetic Engineering and Its Ethical Implications: A Bioethical Perspective. Luminis Applied Science and Engineering, 2(1), 57-64. https://doi.org/10.69760/lumin.20250001010